At Oklahoma Heart Institute (OHI), we don’t believe it’s enough to simply keep up with the latest advances in cardiovascular medicine - we prefer to lead the way. That’s why OHI elects to participate in the research studies sponsored by the Oklahoma Heart Research & Education Foundation. Because OHI participates in these studies, we help bring new treatments to patients sooner. With ongoing studies and clinical trials evaluating treatments for many conditions including valvular disease, high blood pressure, heart failure and coronary artery disease, Oklahoma Heart Institute – and our patients – are at the forefront of innovation.

Featured News

​For information on available research opportunities Oklahoma Heart Research and Education participates click HERE

June 22, 2021 Oklahoma Heart Institute (OHI), in partnership with the Oklahoma Heart Research & Education Foundation and Edwards Lifesciences, was the first center in the world to use the new Edwards PASCAL Precision system for treatment of severe mitral valve regurgitation (leaky heart valve) as part of the CLASP IID/IIF Pivotal Trial on May 25, 2021. This research trial is a prospective, multicenter, randomized, controlled pivotal trial to evaluate the safety and effectiveness of transcatheter mitral valve repair with the Edwards PASCAL Transcatheter Valve Repair System compared to the Abbott MitraClip in patients with degenerative mitral regurgitation (DMR) who have been determined to be at prohibitive risk for open-heart mitral valve surgery by the heart team and in patients with functional mitral regurgitation (FMR) on guideline-directed medical therapy (GDMT).

OHI is pleased to be the first center in the world to utilize the next-generation PASCAL Precision system. OHI is one of 65 major U.S. cardiac centers participating in the CLASP IID/IIF trial. Patients who are enrolled in this trial may be candidates for minimally-invasive, non-surgical transcatheter mitral valve repair to treat their leaky mitral valve with the Edwards PASCAL device.

OHI continues to be the leader in innovation for the treatment of heart disease in Oklahoma and the region.

Dec. 4, 2020 - Oklahoma Heart Institute’s structural heart disease program is pleased to participate in the CLASP II TR trial, sponsored by the Oklahoma Heart Research & Education Foundation (OHREF). The Edwards PASCAL transcatheter valve repair system is being studied in this trial to repair severely leaky tricuspid valves without surgery. Oklahoma Heart Institute – through the OHREF – is the only center in Oklahoma participating in pivotal research studies of non-surgical heart valve repair therapies.

June 25, 2020 – Oklahoma Heart Institute is participating in the SUMMIT Tendyne Trial which is sponsored by the Oklahoma Heart Research & Education Foundation (OHREF). The first three transcatheter mitral valve replacement (TMVR) procedures in Oklahoma were performed at Oklahoma Heart Institute as part of this pivotal clinical trial.

This technology offers a minimally invasive option for This technology offers a minimally invasive option for patients who are high-risk for open heart surgery to treating disabling mitral valve disease if they qualify for the research trial. Transcatheter mitral valve replacement allows for replacement of the failing mitral heart valve while the heart is beating, through a small chest incision.

OHREF is one of 35 major sites across the U.S. participating in the SUMMIT Tendyne Trial. Because we are participating in this sponsored trial, it allows us to offer new technology locally to our patients who qualify for this study.

Oklahoma Heart Institute continues to lead the way in cardiology care and minimally invasive structural heart disease therapy in Oklahoma and the region. Our team also performed the first transcatheter aortic valve replacement (TAVR) in Tulsa in 2012 and the first transcatheter mitral valve repair (MitraClip) in Tulsa in 2014.